Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain.
Identifieur interne : 000896 ( Main/Exploration ); précédent : 000895; suivant : 000897Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain.
Auteurs : Mehmet Esref Alkis [Turquie] ; Hakki Murat Bilgin [Turquie] ; Veysi Akpolat [Turquie] ; Suleyman Dasdag [Turquie] ; Korkut Yegin [Turquie] ; Mehmet Cihan Yavas [Turquie] ; Mehmet Zulkuf Akdag [Turquie]Source :
- Electromagnetic biology and medicine [ 1536-8386 ] ; 2019.
Descripteurs français
- KwdFr :
- Altération de l'ADN, Animaux, Antioxydants (métabolisme), Désoxyguanosine (analogues et dérivés), Désoxyguanosine (métabolisme), Encéphale (effets des radiations), Encéphale (métabolisme), Malonaldéhyde (métabolisme), Monoxyde d'azote (métabolisme), Mâle, Ondes hertziennes (effets indésirables), Peroxydation lipidique (effets des radiations), Rat Sprague-Dawley, Rats, Stress oxydatif (effets des radiations).
- MESH :
- analogues et dérivés : Désoxyguanosine.
- effets des radiations : Encéphale, Peroxydation lipidique, Stress oxydatif.
- effets indésirables : Ondes hertziennes.
- métabolisme : Antioxydants, Désoxyguanosine, Encéphale, Malonaldéhyde, Monoxyde d'azote.
- Altération de l'ADN, Animaux, Mâle, Rat Sprague-Dawley, Rats.
English descriptors
- KwdEn :
- 8-Hydroxy-2'-Deoxyguanosine, Animals, Antioxidants (metabolism), Brain (metabolism), Brain (radiation effects), Cell Phone, DNA Damage, Deoxyguanosine (analogs & derivatives), Deoxyguanosine (metabolism), Lipid Peroxidation (radiation effects), Male, Malondialdehyde (metabolism), Nitric Oxide (metabolism), Oxidative Stress (radiation effects), Radio Waves (adverse effects), Rats, Rats, Sprague-Dawley.
- MESH :
- chemical , analogs & derivatives : Deoxyguanosine.
- chemical , metabolism : Antioxidants, Deoxyguanosine, Malondialdehyde, Nitric Oxide.
- chemical : 8-Hydroxy-2'-Deoxyguanosine.
- adverse effects : Radio Waves.
- metabolism : Brain.
- radiation effects : Brain, Lipid Peroxidation, Oxidative Stress.
- Animals, Cell Phone, DNA Damage, Male, Rats, Rats, Sprague-Dawley.
Abstract
Ubiquitous and ever increasing use of mobile phones led to the growing concern about the effects of radiofrequency radiation (RFR) emitted by cell phones on biological systems. The aim of this study is to explore whether long-term RFR exposure at different frequencies affects DNA damage and oxidant-antioxidant parameters in the blood and brain tissue of rats. 28 male Sprague Dawley rats were randomly divided into four equal groups (n = 7). They were identified as Group 1: sham-control, Group 2: 900 MHz, Group 3: 1800 MHz, and Group 4: 2100 MHz. Experimental groups of rats were exposed to RFR 2 h/day for 6 months. The sham-control group of rats was subjected to the same experimental condition but generator was turned off. Specific absorption rates (SARs) at brain with 1 g average were calculated as 0.0845 W/kg, 0.04563 W/kg, and 0.03957, at 900 MHz, 1800 MHz, and 2100 MHz, respectively. Additionally, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), total antioxidant status (TAS), and total oxidant status (TOS) analyses were conducted in the brain tissue samples. Results of the study showed that DNA damage and oxidative stress indicators were found higher in the RFR exposure groups than in the sham-control group. In conclusion, 900-, 1800-, and 2100-MHz RFR emitted from mobile phones may cause oxidative damage, induce increase in lipid peroxidation, and increase oxidative DNA damage formation in the frontal lobe of the rat brain tissues. Furthermore, 2100-MHz RFR may cause formation of DNA single-strand breaks.
DOI: 10.1080/15368378.2019.1567526
PubMed: 30669883
Affiliations:
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Le document en format XML
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Medeniyet University , Istanbul , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>d Department of Biophysics , Medical School of Istanbul Medeniyet University , Istanbul </wicri:regionArea><wicri:noRegion>Istanbul </wicri:noRegion></affiliation></author><author><name sortKey="Yegin, Korkut" sort="Yegin, Korkut" uniqKey="Yegin K" first="Korkut" last="Yegin">Korkut Yegin</name><affiliation wicri:level="1"><nlm:affiliation>e Department of Electrical and Electronics Engineering , Ege University , Izmir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>e Department of Electrical and Electronics Engineering , Ege University , Izmir </wicri:regionArea><wicri:noRegion>Izmir </wicri:noRegion></affiliation></author><author><name sortKey="Yavas, Mehmet Cihan" sort="Yavas, Mehmet Cihan" uniqKey="Yavas M" first="Mehmet Cihan" last="Yavas">Mehmet Cihan Yavas</name><affiliation wicri:level="1"><nlm:affiliation>f Department of Biophysics , Medical School of Ahi Evran University , Kirsehir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>f Department of Biophysics , Medical School of Ahi Evran University , Kirsehir </wicri:regionArea><wicri:noRegion>Kirsehir </wicri:noRegion></affiliation></author><author><name sortKey="Akdag, Mehmet Zulkuf" sort="Akdag, Mehmet Zulkuf" uniqKey="Akdag M" first="Mehmet Zulkuf" last="Akdag">Mehmet Zulkuf Akdag</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Biophysics , Medical School of Dicle University , Diyarbakir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>c Department of Biophysics , Medical School of Dicle University , Diyarbakir </wicri:regionArea><wicri:noRegion>Diyarbakir </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30669883</idno><idno 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brain.</title><author><name sortKey="Alkis, Mehmet Esref" sort="Alkis, Mehmet Esref" uniqKey="Alkis M" first="Mehmet Esref" last="Alkis">Mehmet Esref Alkis</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Electronics , Engineering and Architecture Faculty of Mus Alparslan University , Mus , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>a Department of Electronics , Engineering and Architecture Faculty of Mus Alparslan University , Mus </wicri:regionArea><wicri:noRegion>Mus </wicri:noRegion></affiliation></author><author><name sortKey="Bilgin, Hakki Murat" sort="Bilgin, Hakki Murat" uniqKey="Bilgin H" first="Hakki Murat" last="Bilgin">Hakki Murat Bilgin</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Physiology , Medical School of Dicle University , Diyarbakir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>b Department of Physiology , Medical School of Dicle University , Diyarbakir </wicri:regionArea><wicri:noRegion>Diyarbakir </wicri:noRegion></affiliation></author><author><name sortKey="Akpolat, Veysi" sort="Akpolat, Veysi" uniqKey="Akpolat V" first="Veysi" last="Akpolat">Veysi Akpolat</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Biophysics , Medical School of Dicle University , Diyarbakir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>c Department of Biophysics , Medical School of Dicle University , Diyarbakir </wicri:regionArea><wicri:noRegion>Diyarbakir </wicri:noRegion></affiliation></author><author><name sortKey="Dasdag, Suleyman" sort="Dasdag, Suleyman" uniqKey="Dasdag S" first="Suleyman" last="Dasdag">Suleyman Dasdag</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Biophysics , Medical School of Istanbul Medeniyet University , Istanbul , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>d Department of Biophysics , Medical School of Istanbul Medeniyet University , Istanbul </wicri:regionArea><wicri:noRegion>Istanbul </wicri:noRegion></affiliation></author><author><name sortKey="Yegin, Korkut" sort="Yegin, Korkut" uniqKey="Yegin K" first="Korkut" last="Yegin">Korkut Yegin</name><affiliation wicri:level="1"><nlm:affiliation>e Department of Electrical and Electronics Engineering , Ege University , Izmir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>e Department of Electrical and Electronics Engineering , Ege University , Izmir </wicri:regionArea><wicri:noRegion>Izmir </wicri:noRegion></affiliation></author><author><name sortKey="Yavas, Mehmet Cihan" sort="Yavas, Mehmet Cihan" uniqKey="Yavas M" first="Mehmet Cihan" last="Yavas">Mehmet Cihan Yavas</name><affiliation wicri:level="1"><nlm:affiliation>f Department of Biophysics , Medical School of Ahi Evran University , Kirsehir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>f Department of Biophysics , Medical School of Ahi Evran University , Kirsehir </wicri:regionArea><wicri:noRegion>Kirsehir </wicri:noRegion></affiliation></author><author><name sortKey="Akdag, Mehmet Zulkuf" sort="Akdag, Mehmet Zulkuf" uniqKey="Akdag M" first="Mehmet Zulkuf" last="Akdag">Mehmet Zulkuf Akdag</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Biophysics , Medical School of Dicle University , Diyarbakir , Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>c Department of Biophysics , Medical School of Dicle University , Diyarbakir </wicri:regionArea><wicri:noRegion>Diyarbakir </wicri:noRegion></affiliation></author></analytic><series><title level="j">Electromagnetic biology and medicine</title><idno type="eISSN">1536-8386</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>8-Hydroxy-2'-Deoxyguanosine</term><term>Animals</term><term>Antioxidants (metabolism)</term><term>Brain (metabolism)</term><term>Brain (radiation effects)</term><term>Cell Phone</term><term>DNA Damage</term><term>Deoxyguanosine (analogs & derivatives)</term><term>Deoxyguanosine (metabolism)</term><term>Lipid Peroxidation (radiation effects)</term><term>Male</term><term>Malondialdehyde (metabolism)</term><term>Nitric Oxide (metabolism)</term><term>Oxidative Stress (radiation effects)</term><term>Radio Waves (adverse effects)</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Altération de l'ADN</term><term>Animaux</term><term>Antioxydants (métabolisme)</term><term>Désoxyguanosine (analogues et dérivés)</term><term>Désoxyguanosine (métabolisme)</term><term>Encéphale (effets des radiations)</term><term>Encéphale (métabolisme)</term><term>Malonaldéhyde (métabolisme)</term><term>Monoxyde d'azote (métabolisme)</term><term>Mâle</term><term>Ondes hertziennes (effets indésirables)</term><term>Peroxydation lipidique (effets des radiations)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Stress oxydatif (effets des radiations)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxyguanosine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Deoxyguanosine</term><term>Malondialdehyde</term><term>Nitric Oxide</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>8-Hydroxy-2'-Deoxyguanosine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radio Waves</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Désoxyguanosine</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Encéphale</term><term>Peroxydation lipidique</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Ondes hertziennes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term><term>Désoxyguanosine</term><term>Encéphale</term><term>Malonaldéhyde</term><term>Monoxyde d'azote</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Brain</term><term>Lipid Peroxidation</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Phone</term><term>DNA Damage</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Altération de l'ADN</term><term>Animaux</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ubiquitous and ever increasing use of mobile phones led to the growing concern about the effects of radiofrequency radiation (RFR) emitted by cell phones on biological systems. The aim of this study is to explore whether long-term RFR exposure at different frequencies affects DNA damage and oxidant-antioxidant parameters in the blood and brain tissue of rats. 28 male Sprague Dawley rats were randomly divided into four equal groups (n = 7). They were identified as Group 1: sham-control, Group 2: 900 MHz, Group 3: 1800 MHz, and Group 4: 2100 MHz. Experimental groups of rats were exposed to RFR 2 h/day for 6 months. The sham-control group of rats was subjected to the same experimental condition but generator was turned off. Specific absorption rates (SARs) at brain with 1 g average were calculated as 0.0845 W/kg, 0.04563 W/kg, and 0.03957, at 900 MHz, 1800 MHz, and 2100 MHz, respectively. Additionally, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), total antioxidant status (TAS), and total oxidant status (TOS) analyses were conducted in the brain tissue samples. Results of the study showed that DNA damage and oxidative stress indicators were found higher in the RFR exposure groups than in the sham-control group. In conclusion, 900-, 1800-, and 2100-MHz RFR emitted from mobile phones may cause oxidative damage, induce increase in lipid peroxidation, and increase oxidative DNA damage formation in the frontal lobe of the rat brain tissues. Furthermore, 2100-MHz RFR may cause formation of DNA single-strand breaks.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Alkis, Mehmet Esref" sort="Alkis, Mehmet Esref" uniqKey="Alkis M" first="Mehmet Esref" last="Alkis">Mehmet Esref Alkis</name></noRegion><name sortKey="Akdag, Mehmet Zulkuf" sort="Akdag, Mehmet Zulkuf" uniqKey="Akdag M" first="Mehmet Zulkuf" last="Akdag">Mehmet Zulkuf Akdag</name><name sortKey="Akpolat, Veysi" sort="Akpolat, Veysi" uniqKey="Akpolat V" first="Veysi" last="Akpolat">Veysi Akpolat</name><name sortKey="Bilgin, Hakki Murat" sort="Bilgin, Hakki Murat" uniqKey="Bilgin H" first="Hakki Murat" last="Bilgin">Hakki Murat Bilgin</name><name sortKey="Dasdag, Suleyman" sort="Dasdag, Suleyman" uniqKey="Dasdag S" first="Suleyman" last="Dasdag">Suleyman Dasdag</name><name sortKey="Yavas, Mehmet Cihan" sort="Yavas, Mehmet Cihan" uniqKey="Yavas M" first="Mehmet Cihan" last="Yavas">Mehmet Cihan Yavas</name><name sortKey="Yegin, Korkut" sort="Yegin, Korkut" uniqKey="Yegin K" first="Korkut" last="Yegin">Korkut Yegin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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